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Injectable Poly(ethylene glycol) Dimethacrylate-based Hydrogels with Hydroxyapatite

State Key Laboratory of Chemical Resource Engineering Key Lab. of Beijing City on Preparation and Processing of Novel Polymer Materials; College of Material Science and Engineering Beijing University of Chemical Technology, Beijing, 100029, P. R. China

Dongzhi Yang

State Key Laboratory of Chemical Resource Engineering Key Lab. of Beijing City on Preparation and Processing of Novel Polymer Materials; College of Material Science and Engineering Beijing University of Chemical Technology, Beijing, 100029, P. R. China

Jun Nie

State Key Laboratory of Chemical Resource Engineering Key Lab. of Beijing City on Preparation and Processing of Novel Polymer Materials; College of Material Science and Engineering Beijing University of Chemical Technology, Beijing, 100029, P. R. China, niejun{at}mail.buct.edu.cn

Yongjuan Ren

Department of Materials Science and Engineering Tsinghua University, Beijing, 100084, P. R. China

Fuzhai Cui

Department of Materials Science and Engineering Tsinghua University, Beijing, 100084, P. R. China

Injectable hydrogels are attractive materials for tissue engineering as they provide fast reaction rates, low heat release, and biocompatibility for cell proliferation and permanent interface with surrounding tissue. A series of injectable poly(ethylene glycol) dimethacrylate (PEGDMA) hydrogels with four different weight fractions of hydroxyapatite (HA) particles were prepared and thermal and mechanical properties evaluated. The cytocompatibility was assessed by examining the viability and morphology of human mesenchymal stem cells (hMSCs) seeded on the hydrogels. The in situ crosslink process displayed a vast decrease in the maximal temperature and an increase in the maximal temperature time. Cytocompatibility evaluation by MTT assay, scanning electron microscopy (SEM) and laser scanning confocal microscopy (LSCM) showed that the cells on the composite hydrogels possessed better viability and adherence than the hydrogels without HA. The results indicated that composite hydrogels have potential as injectable materials for tissue engineering application.

Key Words: biocompatibility • hydroxyapatite • injectable hydrogels • poly (ethylene glycol) dimethacrylate • tissue engineering.

This version was published on September 1, 2009

Journal of Bioactive and Compatible Polymers, Vol. 24, No. 5, 405-423 (2009)
DOI: 10.1177/0883911509341774


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