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Journal of Bioactive and Compatible Polymers
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Delivery of Doxorubicin from Biodegradable PEG Hydrogels Having Schiff Base Linkages{dagger}

Hiroshi Saito

Center for Bioengineering, University of Washington, Seattle WA 98195, USA

Allan S. Hoffman

Center for Bioengineering, University of Washington, Seattle WA 98195, USA, hoffman{at}u.washington.edu

Hiroaki Iyehara Ogawa

Graduate School of Life Science and System Engineering Kyushu Institute of Technology, Kitakyushu Fukuoka 808-0196, Japan

In our quest to develop new drug delivery systems, we designed and synthesized PEG-conjugates and PEG-hydrogels with a degradable linkage to the drug. Specifically, methoxyPEG-doxorubicin (MPEG-CH=N-Doxo) and doxorubicin-PEG aldehyde (OHC-PEG-CH=N-Doxo) conjugates, plus poly (vinyl amine)-PEG-doxorubicin (PVAm-PEG-Doxo) hydrogels were prepared. The hydrogels were crosslinked by PEG-Schiff base linkages, and the Doxo was conjugated to the gel by pendant Schiff base bonds (PVAm-N=CH-PEG-CH=N-Doxo). The release profile of Doxo from the hydrogels was dependent on pH and on the ratio of PVAm to the PEG-dialdehyde crosslinker. These degradable PEG hydrogels could be good candidates for slow release of Doxo from subcutaneous or IM implants.

Key Words: drug delivery • hydrogel • biodegradable • PEG • schiff base • doxorubicin.

Journal of Bioactive and Compatible Polymers, Vol. 22, No. 6, 589-601 (2007)
DOI: 10.1177/0883911507084653
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