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Core/Shell Macrobeads for the Protection of Islets from Immune System Rejection

Department of Polymer Science and Engineering, Hannam University, 133 Ojeong Dong, Daedeog Ku, Taejeon, Korea, 306-791

Jin Ho Lee

Department of Polymer Science and Engineering, Hannam University, 133 Ojeong Dong, Daedeog Ku, Taejeon, Korea, 306-791

Soon Hong Yuk

Department of Polymer Science and Engineering, Hannam University, 133 Ojeong Dong, Daedeog Ku, Taejeon, Korea, 306-791, shyuk{at}hannam.ac.kr

Sun Hee Suh

Department of Immunology, The Catholic University of Korea, St Mary’s Hospital, 505 Banpo Dong, Seocho Ku, Seoul, Korea, 137-040

Kun-Ho Yoon

Department of Immunology, The Catholic University of Korea, St Mary’s Hospital, 505 Banpo Dong, Seocho Ku, Seoul, Korea, 137-040

Core/shell macrobeads, composed of a hydrogel core and a biodegradable polymeric shell, were designed and evaluated for the protection of islets from both fibrous tissue development as well as the modulation of the immune system rejection response. The core/shell macrobeads (2,000µm diameter) were prepared with approximately 150µm thick polymeric shells. Islets isolated from pancreas of C57/BL6 mice were encapsulated in these core/shell macrobeads. The islets-loaded core/shell macrobeads were planted in the peritoneal cavity of diabetes mellitus-induced C57/BL6 mice and the blood glucose concentrations were measured.

Key Words: biodegradeable • hydrogel • coreshell • islets • macrobeads • immune system • blood glucose

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Journal of Bioactive and Compatible Polymers, Vol. 21, No. 1, 71-81 (2006)
DOI: 10.1177/0883911506060146


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Web of Science (1) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Choi, Y. H. Articles by Yoon, K.-H. Search for Related Content Social Bookmarking                         What's this?