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Journal of Bioactive and Compatible Polymers
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Polyanionic Polymers. I. Synthesis, Characterization, and Potential Medical Applications of Benzocaine Modified Carboxymethylcellulose

Constantin V. Uglea

Institute of Biological Research Iassy, Romania

Iulian Narcis Albu

Institute of Biological Research Iassy, Romania

Alina Vatajanu

Institute of Biological Research Iassy, Romania

Mariana Croitoru

Institute of Biological Research Iassy, Romania

Dorina Iurea

Institute of Biological Research Iassy, Romania

Mihai Isac

Alexandru Ioan Cuza University Iassy, Romania

Raphael M. Ottenbrite

Virginia Commonwealth University Richmond, VA

New polymers with antiviral and antitumor activity were syn thesized by introducing benzocaine onto carboxymethylcellulose (CMC) or ox idized carboxymethylcellulose (oxidized CMC). The biological tests (anesthetic, antiviral and antitumor activity) showed that the introduction of benzocaine as a spacer between the main chain and a CMC carboxylic group enhances the an tiviral and antitumor activity of the CMC. The anesthetic effect of benzocaine- modified CMC indicates that benzocaine is not released by hydrolysis from the macromolecular support.

Journal of Bioactive and Compatible Polymers, Vol. 9, No. 4, 448-461 (1994)
DOI: 10.1177/088391159400900406
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