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Journal of Bioactive and Compatible Polymers
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Synthesis of Bioerodible Poly({varepsilon}-caprolactone) Latexes and Poly(D, L-lactide) Microspheres by Ring-Opening Polymerization

S. Sosnowski

Polish Academy of Sciences Center of Molecular and Macromolecular Studies Department of Polymer Chemistry Sienkiewicza 112 90-363 Lodz, Poland

M. Gadzinowski

Polish Academy of Sciences Center of Molecular and Macromolecular Studies Department of Polymer Chemistry Sienkiewicza 112 90-363 Lodz, Poland

S. Slomkowski

Polish Academy of Sciences Center of Molecular and Macromolecular Studies Department of Polymer Chemistry Sienkiewicza 112 90-363 Lodz, Poland

S. Penczek

Polish Academy of Sciences Center of Molecular and Macromolecular Studies Department of Polymer Chemistry Sienkiewicza 112 90-363 Lodz, Poland

Poly({varepsilon}-caprolactone) [poly(CL)] latexes and poly(D,L-lactide) [poly(D,L-Lc)] microspheres were prepared directly by ring-opening precipita tion polymerization carried out in heptane-dioxane (4:1 v/v) mixed solvent in the presence of poly(dodecyl acrylate)-g-poly({varepsilon}-caprolactone) used as the surface active agent. This designed synthetic method yielded latexes and microspheres with narrow size distribution; poly(CL) latex Dv/Dn = 1.038 and for poly(D,L- Lc) microspheres Dv/Dn = 1.15. (Dv and Dn denote the volume and number average diameters of particles.) The poly(CL) latex, synthesized by using CH3CH2OAl(CH2CH3) 2 as initiator, had a narrow polymer polydispersity of 1.11. Poly(D,L-Lc) microspheres, besides polymer with Mw/M n = 1.05 contained some unreacted lactide. Adsorption of human serum albumin and human gamma globulins on both kinds of polyester particles was studied for their potential use as polypeptide and protein delivery systems.

Journal of Bioactive and Compatible Polymers, Vol. 9, No. 4, 345-366 (1994)
DOI: 10.1177/088391159400900401
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