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Journal of Bioactive and Compatible Polymers
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Targeted Delivery of Drugs Provided by Water-Soluble Polymeric Systems with Low Critical Solution Temperature (LCST

Lev I. Valuev

A.V Topchiev Institute of Petrochemical Synthesis of Russian Acad. Sci. Leninsky Prospect 29 Moscow 117071, Russia

Olga N. Zefirova

A.V Topchiev Institute of Petrochemical Synthesis of Russian Acad. Sci. Leninsky Prospect 29 Moscow 117071, Russia

Irina V. Obydennova

A.V Topchiev Institute of Petrochemical Synthesis of Russian Acad. Sci. Leninsky Prospect 29 Moscow 117071, Russia

Nikolai A. Plate

A.V Topchiev Institute of Petrochemical Synthesis of Russian Acad. Sci. Leninsky Prospect 29 Moscow 117071, Russia

A new approach to the targeted thermally activated transport of chemical agents and physiologically active compounds is reported. The method involves the immobilization of these compounds on a water-soluble polymer with a low critical solution temperature and heating the delivery site above the critical temperature. The approach was illustrated with trypsin immobilized on N-isopropylacrylamide-acrylamide-N-acryloylphthalimide ternary copoly mers.

Journal of Bioactive and Compatible Polymers, Vol. 9, No. 1, 55-65 (1994)
DOI: 10.1177/088391159400900103
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V. Chtryt and K. Ulbrich
Conjugate of Doxorubicin with a Thermosensitive Polymer Drug Carrier
Journal of Bioactive and Compatible Polymers, November 1, 2001; 16(6): 427 - 440.
[Abstract] [PDF]