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Journal of Bioactive and Compatible Polymers
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Macromolecular Drug Conjugates II. Metronidazole-Dextran Prodrugs

Georgeta Mocanu

"Petru Poni" Institute of Macromolecular Chemistry 6600 Jassy, Romania

Anton Airinei

"Petru Poni" Institute of Macromolecular Chemistry 6600 Jassy, Romania

Adrian Carpov

"Petru Poni" Institute of Macromolecular Chemistry 6600 Jassy, Romania

The antimicrobial drug metronidazole was attached to dextran. Two methods of dextran-metronidazole synthesis were studied: (1) the reaction of metronidazole with chloroacetylated derivatives of crosslinked dextran microparticles in basic aprotic solvents, and (2) the reaction of metronidazole chloroacetic acid ester with crosslinked dextran microparticles in basic media. The release of metronidazole from the two types of macromolecular prodrugs was compared.

Journal of Bioactive and Compatible Polymers, Vol. 8, No. 4, 383-392 (1993)
DOI: 10.1177/088391159300800406
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