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Journal of Bioactive and Compatible Polymers
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Experimental Wound Dressing by Heterologous Collagen: A Morphological-Quantitative Approach

M. Mattioli Belmonte

Institute of Human Morphology Facoltà di Medicina Università degli Studi di Ancona Via R Ranieri, 6 60131 Ancona, Italy

G. Biagini

Institute of Human Morphology Facoltà di Medicina Università degli Studi di Ancona Via R Ranieri, 6 60131 Ancona, Italy

G. Ricotti

Clinic of Dermatology Osp. Umberto I University of Ancona 60100 Ancona, Italy

C. Zucchini

Institute of Histology and Embriology University of Bologna Via Belmeloro 8 40126 Bologna, Italy

C. Castaldini

Institute of Histology and Embriology University of Bologna Via Belmeloro 8 40126 Bologna, Italy

M. Fini

Experimental Surgery I.O.R. Via di Barbiano 1/10 40136 Bologna, Italy

R. Giardino

Experimental Surgery I.O.R. Via di Barbiano 1/10 40136 Bologna, Italy

M. Bigini

Gentili Institute S.p.A. Via Mazzini 112 Pisa, Italy

The use of heterologous collagen in skin repair processes has proved to be an efficacious approach for the reconstitution of injured tissue. A morphological and quantitative evaluation of the reactive and reparative ca pacity of injured tissue treated either with conventional medications or with heterologous collagen (Condress) in the form of sponges was carried out. We have analyzed experimental surgical lesions on an animal model and evalu ated the repair processes of the lesions, including the excision of the cutaneous and subcutaneous tissue. The heterologous collagen sponges provided biologi cal support to obtain healed skin of better quality. Tissue lesions healed more rapidly, thus reducing the risk of recurrence. This experimental study provides morphological and structural data for further investigation.

Journal of Bioactive and Compatible Polymers, Vol. 8, No. 4, 365-382 (1993)
DOI: 10.1177/088391159300800405
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