Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Bioactive and Compatible Polymers
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Fukui, H.
Right arrow Articles by Numata, M.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Anticancer Activity of Polyunsaturated Fatty Acid Emulsion Stabilized by Hydrophobized Polysaccharide

Hiroki Fukui

Laboratory of Materials Science of Polymers Department of Polymer Chemistry Kyoto University Sakyo-ku, Yoshida Hommachi, Kyoto 606, Japan

Kazunari Akiyoshi

Laboratory of Materials Science of Polymers Department of Polymer Chemistry Kyoto University Sakyo-ku, Yoshida Hommachi, Kyoto 606, Japan

Toshinori Sato

Laboratory of Materials Science of Polymers Department of Polymer Chemistry Kyoto University Sakyo-ku, Yoshida Hommachi, Kyoto 606, Japan

Junzo Sunamoto

Laboratory of Materials Science of Polymers Department of Polymer Chemistry Kyoto University Sakyo-ku, Yoshida Hommachi, Kyoto 606, Japan

Shigehiko Yamaguchi

Nippon Oil & Fats, Co., Ltd. Tsukuba Research Laboratory Tsukuba 300-26, Japan

Mituhiro Numata

Department of Bioactive Molecules National Institute of Health Shinjuku-ku, Tokyo, Japan

An oil-in-water emulsion of selectively cytotoxic {alpha}-linolenic acid (ALA, C18:3{omega}3) was stabilized with cholesterol-bearing pullulan (CHP-55-2.1), and the in vivo anticancer effect of the O/W-emulsion was investigated. The O/W-emulsion was prepared by ultrasonication of a mixture of CHP and ALA in the presence or absence of trioctanoylglyceride (TriC8). The colloidal stabil ity of the CHP/ALA-emulsion was largely improved by adding TriC8. Intraperi toneal injection of the CHP/ALA-emulsion effectively prolonged the survival time of C3H/He mice which received an intraperitoneal transplantation of MM46 mammary tumor cells. The growth of these tumor cells subcutaneously transplanted in C3H/He mice was also significantly suppressed without any loss of body weight when CHP/ALA/TriC8-emulsion was intravenously injected. By using this colloidally stable O/W emulsion, it is possible to systemically ad minister a lipophilic liquid drug.

Journal of Bioactive and Compatible Polymers, Vol. 8, No. 4, 305-316 (1993)
DOI: 10.1177/088391159300800401
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?