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Journal of Bioactive and Compatible Polymers
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Synthesis and Evaluation of Heparinized Biocompatible Materials Using Heparin/Surface-Active Compound Complexes

Takashi Kashiwagi

Department of Polymer Chemistry Kyoto University Kyoto, 606-01, Japan

Yoshihiro Ito

Department of Polymer Chemistry Kyoto University Kyoto, 606-01, Japan

Yukio Imanishi

Department of Polymer Chemistry Kyoto University Kyoto, 606-01, Japan

Heparin, an antithrombogenic mucopolysaccharide, forms com plexes with lecithin and other surface-active compounds (SAC). The complexes are soluble in organic solvents. The heparin/SAC complexes have antithrombo genic activity similar to heparin. Heparinized materials, in which the heparin/SAC complexes were used, showed an excellent in vitro nonthrombo genicity. The heparinized materials do not influence in vitro cell growth and showed an excellent biocompatibility.

Journal of Bioactive and Compatible Polymers, Vol. 8, No. 3, 275-288 (1993)
DOI: 10.1177/088391159300800306
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