Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Bioactive and Compatible Polymers
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Yang, J.-Z.
Right arrow Articles by Ottenbrite, R. M.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Synthesis of Copoly(amino acids) as Potential Biomaterials by Diphenyl Phosphoryl Azide

Jian-Zhong Yang

Department of Chemistry Virginia Commonwealth University Richmond, VA 23284

Min Wang

Department of Chemistry Virginia Commonwealth University Richmond, VA 23284

Raphael M. Ottenbrite

Department of Chemistry Virginia Commonwealth University Richmond, VA 23284

A convenient chemical synthesis of copoly(amino acids) as poten tial biomaterials is described. Direct copolycondensations of {alpha}-amino acids us ing diphenyl phosphoryl azide (DPPA) as condensation agent were carried out in the presence of triethylamine (TEA) as a base. The amino acids used were ß-benzyl-L-aspartate (Asp.Bz), {gamma}-benzyl-L-glutamate (Glu.Bz), L-phenylalanine (Phe), and O-benzyl-L-tyrosine (Tyr.OBz). Copoly(amino acids) with weight- average molecular weights up to 28,000 were obtained in reasonable yields. Bimodal molecular weight distribution was observed in all the cases. Both the overall yield of the product and the yield of high molecular weight fraction are influenced by [DPPA]/[Monomer] and [TEA]/[Monomer] ratios. No significant solvent effect was observed.

Journal of Bioactive and Compatible Polymers, Vol. 8, No. 1, 69-82 (1993)
DOI: 10.1177/088391159300800105
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?