Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Bioactive and Compatible Polymers
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Shalaby, W. S.W.
Right arrow Articles by Park, K.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Synthesis of Enzyme-Digestible, Interpenetrating Hydrogel Networks by Gamma-Irradiation

Waleed S.W. Shalaby

Purdue University Schools of Pharmacy and Veterinary Medicine West Lafayette, IN 47907

Osalind Jackson

Purdue University Schools of Pharmacy and Veterinary Medicine West Lafayette, IN 47907

William E. Blevins

Purdue University Schools of Pharmacy and Veterinary Medicine West Lafayette, IN 47907

Kinam Park

Purdue University Schools of Pharmacy and Veterinary Medicine West Lafayette, IN 47907

{gamma}-Irradiation was used to prepare cylindrically shaped, enzyme- digestible hydrogels consisting of a moderately swelling albumin-crosslinked poly(vinyl pyrrolidone) (PVP) hydrogel core which formed a semi-interpene trating network (SIPN) at its outer region with a polyelectrolyte homopolymer of acryloxyethyltrimethylammonium chloride (AETAC). In pepsin-free simu lated gastric fluid (SGF), the presence of a SIPN resulted in only a marginal in crease in swelling as compared to the pure PVP hydrogel. In distilled deionized water, however, the swelling of the 2-phase hydrogel system was dramatically increased.

The effects of {gamma}-irradiation on the individual constituent polymers that com prised the 2-phase system were studied. Vinyl pyrrolidone (VP) formed PVP which subsequently crosslinked to form an insoluble three-dimensional net work after 4 h of {gamma}-irradiation. Polymers of AETAC (PAETAC) underwent chain scission following 30 min of {gamma}-irradiation. FA became crosslinked as deter mined by sodium dodecylsulfate-polyacrylamide gel electrophoresis (SDS- PAGE).

The swelling properties of albumin-crosslinked PVP and albumin- crosslinked PAETAC hydrogels were also studied as a function of {gamma}-irradiation time and the concentration of FA in the monomer solution. The equilibrium swelling ratios of the prepared hydrogels in pepsin-free simulated gastric fluid (SGF) were dependent on the {gamma}-irradiation time which affected the crosslinking or chain scission of the polymers. Both the PVP and PAETAC hydrogels under went bulk degradation in pepsin-containing SGF.

Journal of Bioactive and Compatible Polymers, Vol. 8, No. 1, 3-23 (1993)
DOI: 10.1177/088391159300800101
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?