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Journal of Bioactive and Compatible Polymers
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Synthesis, Characterization, and Biological Activity of Polyanion-cis-diammineplatinum(II) Complexes as Antitumor Agents

Man Jung Han

Department of Applied Chemistry Ajou University, Suwon 440-749 Republic of Korea

Tae Joon Cho

Department of Applied Chemistry Ajou University, Suwon 440-749 Republic of Korea

Shin Joon Park

Department of Applied Chemistry Ajou University, Suwon 440-749 Republic of Korea

Youn Soo Sohn

Inorganic Chemistry Lab Korea Institute of Science and Technology P.O. Box 131 Cheongryang, Seoul 130-650 Republic of Korea

Chong Ock Lee

Pharmaceutical Screening Center Korea Research Institute of Chemical Technology Daejeon 305-606, Republic of Korea

Sang Un Choi

Pharmaceutical Screening Center Korea Research Institute of Chemical Technology Daejeon 305-606, Republic of Korea

Polyanion-cis-diammineplatinum(II) complexes were synthesized by the reaction of cis-[Pt(NH3)2(OH2)2](NO 3)2 with the polyanions containing vic- dicarboxylate ions along the polymer chain. The eleven polyanions used for this synthesis were the hydrolysis products of polymers obtained by radical alternating copolymerizations of maleic anhydride with dihydropyran deriva tives. For example, poly[(tetrahydropyran-5,6-diyl)(1,2-dicarboxyethylene)] de rivatives were synthesized, which contained substituents, such as hydroxy, methoxy, ethoxy, acetoxy, methoxycarbonyl and acetoxymethyl groups, on the 2, 3 and 4-positions of the tetrahydropyran ring. The complex formation of cis diammineplatinum(II) with vic-dicarboxylate groups was confirmed by the absorption at 1350 cm -1 for {gamma}s(CO) coordinated with Pt(II). By changing the mole ratios of the reactants, the platinum content in the polyanion complexes can be controlled and every 5-15 repeating units of the polymers were found to contain one cis-diammineplatinum(II). The biological activity of the poly anion-Pt complexes as measured in vitro against A-549 nonsmall cell lung, SK-OV-3 ovarian, HCT-15 colon, XF-498 CNS and L1210 leukemia. After select ing active complexes, the increased life spans were measured against L1210 and found to be 244, 143 and 178% for the complexes (8), (13) and (16), respec tively.

Journal of Bioactive and Compatible Polymers, Vol. 7, No. 4, 358-369 (1992)
DOI: 10.1177/088391159200700405
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