This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Mascarenhas, O. C. Articles by Eckert, R. L. Search for Related Content Social Bookmarking                         What's this?

Development of a Novel Hydrophilic, Biocompatible Adhesive

Departments of Chemistry and Biomedical Engineering The University of Akron Akron, OH 44325

Daniel J. Smith

Departments of Chemistry and Biomedical Engineering The University of Akron Akron, OH 44325

Sheila Andreatta-Van Leyen

Department of Physiology and Biophysics School of Medicine Case Western Reserve University Cleveland, OH 44106

Richard L. Eckert

Department of Physiology and Biophysics School of Medicine Case Western Reserve University Cleveland, OH 44106

The synthesis of two novel hydrogel adhesive films, poly(butoxy- Entprol) and poly(butoxy/ethylene-Entprol) was accomplished by crosslinking either epoxy end-capped oligomeric-butoxy-Entprol or epoxy end-capped oligo meric-butoxy/ethylene-Entprol with 5-10 mole% diethylenetriamine. The two oligomers with Mn 1700 to 5000 were obtained in a 78-87% yield, by the reac tion of one equivalent of N,N'-bis(2-hydroxypropyl)ethylenediamine with either one equivalent of 1,4-butanediol diglycidyl ether or one equivalent of a 1:1 mole ratio mixture of 1,2,7,8-diepoxyoctane and 1,4-butanediol diglycidyl ether.

Peel adhesion to glass for poly(BE) and poly(BEE) gave peel forces of 12.02 and 13.61 N, respectively, as compared to five acrylate adhesives, ranging from 4.90-11.56 N. Poly(BE) had superior adhesion to skin (3.45 N) compared to poly(BEE) (0.97 N) and the acrylate-based adhesives (0.79-2.64 N). In addition, fully hydrated poly(BE) and poly(BEE) have both a high water uptake (971% and 630%, respectively) and equilibrium water content (90% and 86%, respec tively). Both films lose adhesion with progressive hydration. These hydrogels actively support the growth of 3T3 fibroblasts and SCC-13 epithelial cells. These results strongly support the potential of these films as single-layered adhesive hydrogel dressings.

Journal of Bioactive and Compatible Polymers, Vol. 7, No. 4, 324-336 (1992)
DOI: 10.1177/088391159200700402


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?