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Poly(Glyceryl Methacrylate) Hydrogels - Effect of Composition and Crosslinking Density on Structure and Release of Dextran as a Model Macromolecule

Biological Sciences University of Keele, Keele Staffordshire ST5 5BG United Kingdom

G. Maghami

Biological Sciences University of Keele, Keele Staffordshire ST5 5BG United Kingdom

R. Duncan

Biological Sciences University of Keele, Keele Staffordshire ST5 5BG United Kingdom

A series of hydrogels based on glyceryl methacrylate (pGMA) were prepared with different ratios of ethylene glycol dimethacrylate (EGDMA) and ethyl methacrylate (EMA) in order to vary the degree of crosslinking and the degree of hydrophobicity of the matrices, respectively. The swelling be haviour and the crosslinking density of the hydrogels were characterized and the structure was determined by scanning electron microscopy and porosime try. FITC-dextran (molecular weight 20,000) was imbibed into the gels and the release rate studied. It was found that the initial rate of release and the total amount of dextran release varied as an inverse function of crosslinking and monomer concentration, but as a linear function of EMA concentration.

Journal of Bioactive and Compatible Polymers, Vol. 7, No. 4, 305-323 (1992)
DOI: 10.1177/088391159200700401


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