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Journal of Bioactive and Compatible Polymers
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Biocompatibility of Biopolymers

I. Volfova

Institute of Microbiology Czechoslovak Academy of Sciences Vídenská 1083 142 20 Prague 4, Czechoslovakia

B. Ríhová

Institute of Microbiology Czechoslovak Academy of Sciences Vídenská 1083 142 20 Prague 4, Czechoslovakia

V. VetviCKa

Institute of Microbiology Czechoslovak Academy of Sciences Vídenská 1083 142 20 Prague 4, Czechoslovakia

P. Rossmann

Institute of Microbiology Czechoslovak Academy of Sciences Vídenská 1083 142 20 Prague 4, Czechoslovakia

K. Ulbrich

Institute of Macromolecular Chemistry Czechoslovak Academy of Sciences 162 06 Prague, Czechoslovakia

This study examines the biocompatibility of two different syn thetic copolymers; a water soluble copolymer based on [N-(2-hydroxypropyl) methacrylamide] (HPMA) and an insoluble polymer based on 2-hydroxyethyl methacrylate (HEMA). Activation of classical and alternative complement pathways, phagocytic function, bone marrow status, and humoral immune re sponses were assessed after long-term application of the copolymers to mice of the C57BL/10ScSn strain. Histological examination was also performed on sec tions of liver, spleen and kidney. Our results indicate that a total dose of 2 g of HPMA copolymer/1 kg of body weight and 2.5 x 109 particles/mouse of HEMA microspheres did not affect any of the immune parameters that were studied.

Key Words: N-(2-hydroxypropyl)methacrylamide • 2-hydroxyethylmeth acrylate • phagocytic function • complement pathways • immune response • biocompatible polymers.

Journal of Bioactive and Compatible Polymers, Vol. 7, No. 2, 175-190 (1992)
DOI: 10.1177/088391159200700205
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