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Journal of Bioactive and Compatible Polymers
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Partial Esters of Alternating Copolymers of Maleic Anhydride and Alkyl Vinyl Ethers for Pharmaceutical Applications

Emo Chiellini

Dipartimento di Chimica e Chimica Industriale Università di Pisa Via Risorgimento 35 56100 Pisa, Italy

Giuseppe Leonardi

Dipartimento di Chimica e Chimica Industriale Università di Pisa Via Risorgimento 35 56100 Pisa, Italy

Donatella Giannasi

Dipartimento di Chimica e Chimica Industriale Università di Pisa Via Risorgimento 35 56100 Pisa, Italy

Roberto Solaro

Dipartimento di Chimica e Chimica Industriale Università di Pisa Via Risorgimento 35 56100 Pisa, Italy

The synthesis, characterization, and reactivity of alternating copolymers of maleic anhydride (MA) with new vinyl ethers of mono-O-methyl oligoethylene glycol (MePegnVE, degree of oligomerization n = 1-4) are described. The linear MA/PegnVE copolymers were partially esterified with alcohols such as methanol, ethanol, n-butanol, methoxyethanol, and n- dodecanol. Depending upon the nature of the two reactive components, the degree of esterification was between 10 and 70%. Semiquantitative indications on the relative reactivity of both polymeric materials and alcohols are pro vided. The potential of this new class of functional polymers is to provide am phiphilic polymeric ionomers as candidates for drug controlled release, based on their biocompatibility.

Key Words: alternating copolymerization • alkyl vinyl ethers • maleic an hydride • monomethyl oligoethylene glycol vinyl ethers • reactive polymers • polymeric ionomers.

Journal of Bioactive and Compatible Polymers, Vol. 7, No. 2, 161-174 (1992)
DOI: 10.1177/088391159200700204
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