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Journal of Bioactive and Compatible Polymers
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Percolation and Release of Cisplatin Loaded in Poly(lactide-co-glycolide) Microspheres for Chemoembolization

M. Deyme

Laboratoire de Physico-Chimie des Surfaces et Innovation en Pharmacotechnie U.R.A. CNRS 1218 Université Paris-Sud 5 Rue J.-B. Clément 92296 Chatenay-Malabry Cedex, France

G. Spenlehauer

Institut de Biopharmacie Rhône-Poulenc 20 Avenue Raymond Aron 92160 Antony, France

J.-P. Benoit

Laboratoire de Pharmacie Galénique Faculté de Pharmacie 16 Boulevard Daviers 49100 Angers Cedex, France

The dissolution kinetics, in an aqueous medium, of a water solu ble drug dispersed in an insoluble polymeric matrix, depends highly on the drug loading. A computer model of cisplatin loaded poly(lactide-co-glycolide) microspheres dissolution confirms the hypothesis that only the drug crystals connected to the surface of the microspheres are capable of dissolving through a site percolation mechanism. This behavior may also be possible with other drug release systems, limiting their use for controlled release.

Key Words: percolation • cisplatin • poly(lactide-co-glycolide) • microspheres • chemoembolism • model • modelling • lattice.

Journal of Bioactive and Compatible Polymers, Vol. 7, No. 2, 149-160 (1992)
DOI: 10.1177/088391159200700203
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