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Journal of Bioactive and Compatible Polymers
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Role of N-Carboxybutyl Chitosan in the Repair of the Meniscus

R. Muzzarelli

Institute of Biochemistry Faculty of Medicine University of Ancona Ancona, Italy

V. Bicchiega

Institute of Biochemistry Faculty of Medicine University of Ancona Ancona, Italy

G. Biagini

Institute of Human Morphology Faculty of Medicine University of Ancona Ancona, Italy

A. Pugnaloni

Institute of Human Morphology Faculty of Medicine University of Ancona Ancona, Italy

R. Rizzoli

Institute of Anatomy Faculty of Medicine University of Bologna Bologna, Italy

N-Carboxybutyl chitosan obtained from crustacean chitin was used to assist the spontaneous tissue repair of the meniscus, which is usually of extreme difficulty. Results indicate that this natural modified polysaccharide is well-tolerated at the articular synovial level. It also favors and stimulates the repair processes which do not take place spontaneously in the meniscus. N-Carboxybutyl chitosan, therefore, plays a role which helps in repairing meniscal lesions.

Key Words: chitosan • N-carboxybutyl chitosan • polysaccharide • meniscus • synovial membrane.

Journal of Bioactive and Compatible Polymers, Vol. 7, No. 2, 130-148 (1992)
DOI: 10.1177/088391159200700202
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