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Journal of Bioactive and Compatible Polymers
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Epidermal Growth Factor in Cutaneous Repair Processes

G. Ricotti

Faculty of Medicine University of Ancona Via P. Ranieri-Monte d'Ago 60131 Ancona Italy

M.G. Tucci

Faculty of Medicine University of Ancona Via P. Ranieri-Monte d'Ago 60131 Ancona Italy

A. Pugnaloni

Faculty of Medicine University of Ancona Via P. Ranieri-Monte d'Ago 60131 Ancona Italy

G. Biagini

Faculty of Medicine University of Ancona Via P. Ranieri-Monte d'Ago 60131 Ancona Italy

A. Belligolli

Faculty of Medicine University of Ancona Via P. Ranieri-Monte d'Ago 60131 Ancona Italy

A. Bertani

Faculty of Medicine University of Ancona Via P. Ranieri-Monte d'Ago 60131 Ancona Italy

R. Castagnani

C.E.D.U.A. Faculty of Engineering University of Ancona Italy

C. Castaldini

Institute of Histology Faculty of Medicine University of Bologna Italy

Donor areas on patients undergoing plastic surgery were treated with epidermal growth factor (EGF) to stimulate tissue regeneration. Mor phometric analyses showed that cutaneous explants, treated with EGF, pre sented a higher number of microvessels (p < 0.01) and mesenchimal cells (p < 0.01), than untreated areas, while EGF did not improve epidermal thick ening. By electron microscopy, better histoarchitectural maturation of cellular and extracellular dermal compartments was observed after EGF application. This work provides evidence that EGF does stimulate skin repair by promoting the formation of mature cutaneous tissue.

Journal of Bioactive and Compatible Polymers, Vol. 7, No. 1, 65-81 (1992)
DOI: 10.1177/088391159200700107


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