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Journal of Bioactive and Compatible Polymers
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Synthesis and Physiological Genetic Effects of 1-(Methacryloyloxyethyl)- 5-Fluorouracil and Its Polymers

Chang Sik Ha

Department of Polymer Science and Engineering Pusan National University Pusan 609-735, Korea

Won Moon Choi

Department of Polymer Science and Engineering Pusan National University Pusan 609-735, Korea

Ik Sung Kim

Department of Polymer Science and Engineering Pusan National University Pusan 609-735, Korea

Won Jei Cho

Department of Polymer Science and Engineering Pusan National University Pusan 609-735, Korea

Neung Ju Lee

Department of Premedical Sciences Kosin Medical College Pusan 602-030, Korea

The monomer 1-(methacryloyloxyethyl)-5-fluorouracil (MAO EFU) was synthesized from 2,4-bis(trimethylsilyloxy)-5-fluoropyrimidine. Poly- (MAOEFU) and poly(MAOEFU-co-methyl methacrylate) were obtained by radical polymerization at 60°C. The monomer reactivity ratios, r1 and r2 were determined by the Kelen-Tüdös method; r, (MAOEFU) = 0.77 and r2(MMA) = 1.13. The physiological genetic effect of MAOEFU and its polymers in Dro sophila melanogaster was investigated and found that MAOEFU, poly- (MAOEFU) and poly(MAOEFU-co-MMA) are considerably less effective than 5- fluorouracil.

Journal of Bioactive and Compatible Polymers, Vol. 7, No. 1, 39-53 (1992)
DOI: 10.1177/088391159200700105
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