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Synthesis and Interaction Studies on Water Soluble Nucleic Acid Analogs: Poly(L-lysine) Derivatives Containing Thymine and Hypoxanthine*

Department of Applied Fine Chemistry Faculty of Engineering Osaka University Suita, Osaka 565, Japan

Yoshiaki Inaki

Department of Applied Fine Chemistry Faculty of Engineering Osaka University Suita, Osaka 565, Japan

Kiichi Takemoto

Department of Applied Fine Chemistry Faculty of Engineering Osaka University Suita, Osaka 565, Japan

Nucleic acid analogs were prepared by grafting nucleic acid base derivatives containing hydroxy groups onto poly(L-lysine). The polymers con tained about 70 unit% of the nucleic acid bases, and were easily soluble in water at neutral pH value. Conformational changes and polymer complexes with polynucleotides [Poly(A) and Poly(C)] were observed with specific base- base interactions in aqueous solution.

Journal of Bioactive and Compatible Polymers, Vol. 7, No. 1, 25-38 (1992)
DOI: 10.1177/088391159200700104


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