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Journal of Bioactive and Compatible Polymers
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Modified Polyanionic Polymers. I: Grafting of Hydrophobic Group onto Poly(maleic acid-alt-3,4- dihydroxyphenylprop-1-ene) to Improve the Affinity for Cell Membranes

Yasuo Suda

Department of Chemistry Faculty of Science, Osaka University Toyonaka, Osaka 560, Japan

Hitomi Yamamoto

Faculty of Pharmaceutical Sciences Setsunan University Hirakata, Osaka 573-01, Japan

Masao Sumi

Faculty of Pharmaceutical Sciences Setsunan University Hirakata, Osaka 573-01, Japan

Naoto Oku

Faculty of Pharmaceutical Sciences Setsunan University Hirakata, Osaka 573-01, Japan

Fumiaki Ito

Faculty of Pharmaceutical Sciences Setsunan University Hirakata, Osaka 573-01, Japan

Shinji Yamashita

Faculty of Pharmaceutical Sciences Setsunan University Hirakata, Osaka 573-01, Japan

Tanekazu Nadai

Faculty of Pharmaceutical Sciences Setsunan University Hirakata, Osaka 573-01, Japan

Raphael M. Ottenbrite

Department of Chemistry Virginia Commonwealth University Richmond, VA 23284, US.A.

To improve the affinity of polyanionic polymers for cell mem branes, several hydrophobic groups were grafted onto poly(maleic acid-alt- 3,4-dihydroxyphenylprop-1-ene) [poly(MA-alt-DP)] which has cytotoxic activity. The effect of the degree of substitution of the grafted group to the maleic anhy dride residue was also evaluated. Grafted polymers were characterized by their partition coefficients, their affinity to liposomes and their ability to interact with rat small intestinal epithelial cells. It was found that the cell affinity of the modified polyanionic polymers could be augmented and controlled by simple grafting.

Journal of Bioactive and Compatible Polymers, Vol. 7, No. 1, 15-24 (1992)
DOI: 10.1177/088391159200700103
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Y. Suda, S. Kusumoto, N. Oku, H. Yamamoto, M. Sumi, F. Ito, and R. M. Ottenbrite
Modified Polyanionic Polymers for Enhanced Cell Membrane Interaction
Journal of Bioactive and Compatible Polymers, January 1, 1992; 7(3): 275 - 287.
[Abstract] [PDF]