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Journal of Bioactive and Compatible Polymers
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Hydrophilic and Hydrophobic Polymeric Derivatives of Anti-Inflammatory Agents Such as Alclofenac, Ketoprofen, and Ibuprofen

Gaetano Giammona

Dipartimento di Chimica e Tecnologie Farmaceutiche Universita'di Palermo via Archirafi 32 90123 Palermo (Italy)

Bianca Carlisi

Dipartimento di Chimica e Tecnologie Farmaceutiche Universita'di Palermo via Archirafi 32 90123 Palermo (Italy)

Giovanna Pitarresi

Dipartimento di Chimica e Tecnologie Farmaceutiche Universita'di Palermo via Archirafi 32 90123 Palermo (Italy)

Giacomo Fontana

Dipartimento di Chimica e Tecnologie Farmaceutiche Universita'di Palermo via Archirafi 32 90123 Palermo (Italy)

Macromolecular prodrugs of a hydrophilic polymer [{alpha},ß-poly( N- hydroxyethyl)-DL-aspartamide (PHEA)] was used as a drug carrier. Three poly- (HEA)-NSAID adducts were studied: poly(HEA)-Alclofenac, poly(HEA)-Keto profen, and poly(HEA)-Ibuprofen. Prodrugs with different drug content were synthesized both as water-soluble and water-insoluble agents. Hydrolysis of water-soluble adducts in a simulated gastric juice was studied.

Journal of Bioactive and Compatible Polymers, Vol. 6, No. 2, 129-141 (1991)
DOI: 10.1177/088391159100600202
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