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Selective Labeling of Bioactive Polysaccharides with a New Fluorescent Reagent

Department of Chemistry Setsunan University 45-1, Nagaotogecho Hirakata, Osaka 573-01, Japan

Masao Sumi

Department of Chemistry Setsunan University 45-1, Nagaotogecho Hirakata, Osaka 573-01, Japan

Michael Sobel

Department of Surgery Medical College of Virginia Virginia Commonwelath University Box 108, MCV Station Richmond, VA 23298, USA

Raphael M. Ottenbrite

Department of Chemistry Virginia Commonwealth University Box 2006, 1001 West Main Richmond, VA 23284-2006, USA

The selective labeling of polysaccharides by the hydroxyl groups and without loosing biological activity is described. The new reagent is a deriv ative of fluoresceinamine and should be useful for the appropriate labeling of several types of biological active materials containing both amino and hydroxyl functional groups.

Journal of Bioactive and Compatible Polymers, Vol. 5, No. 4, 412-419 (1990)
DOI: 10.1177/088391159000500403


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