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Collagen-Poly(HEMA) Hydrogels for the Controlled Release of Anticancer Drugs—Preparation and Characterization

Biomaterials Division Central Leather Research Institute Adyar, Madras 600020, India

K. Panduranga

Biomaterials Division Central Leather Research Institute Adyar, Madras 600020, India

Copolymeric hydrogels of collagen and poly(hydroxyethyl meth acrylate) [poly(HEMA)] were prepared and were characterized using FT-IR spectroscopy, thermogravimetric analysis (TGA) and scanning electron micros copy (SEM). It was found that hydrogels containing about 5-10% (w/w) collagen were stable and resilient. As the collagen content was increased, there was a corresponding decrease in the resiliency and stability of the hydrogel in retain ing its physical form. The cumulative in vitro release profile of 5-fluorouracil from collagen-poly(HEMA) hydrogel matrix showed a zero-order pattern with a release rate of about 270 µg/day for a period of 10 days.

Journal of Bioactive and Compatible Polymers, Vol. 5, No. 2, 194-211 (1990)
DOI: 10.1177/088391159000500204


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