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Journal of Bioactive and Compatible Polymers
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Polymer Drugs and Polymeric Drugs, Part VII*: Antitumor Conjugated Polymeric Drugs Consisting of 5-Fluorouracil and Polyanionic Polymers

Eiji Yashima

Department of Applied Chemistry Faculty of Engineering Kagoshima University 1-21-40 Korimoto, Kagoshima 890, Japan

Satoshi Uchida

Department of Applied Chemistry Faculty of Engineering Kagoshima University 1-21-40 Korimoto, Kagoshima 890, Japan

Mitsuru Akashi

Department of Applied Chemistry Faculty of Engineering Kagoshima University 1-21-40 Korimoto, Kagoshima 890, Japan

Noriyuki Miyauchi

Department of Applied Chemistry Faculty of Engineering Kagoshima University 1-21-40 Korimoto, Kagoshima 890, Japan

Norikazu Morita

Department of Health Care and Administration School of Medacine Fukuoka University 7-45-1 Nanakuma, Jonanku, Fukuoka 814-01, Japan

Tomonori Minota

Department of Health Care and Administration School of Medacine Fukuoka University 7-45-1 Nanakuma, Jonanku, Fukuoka 814-01, Japan

Derivatives of 5-flurorouracil 1-N-p-vinylbenzoyl-5-fluorouracil (VBFU) were prepared and the solvolysis rates were determined and compared with other 1-N-substituted 5-fluorouracils. VBFU was homopolymerized and copolymerized with maleic anhydride or poly(ethylene glycol) macromonomer. The hydrolysis of these polymeric drugs was studied in a phosphate buffer solu tion, and in vivo antitumor activity was evaluated using Ehrlich's ascites or Sarcoma 180 tumor-bearing mice.

Journal of Bioactive and Compatible Polymers, Vol. 5, No. 1, 53-64 (1990)
DOI: 10.1177/088391159000500106
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