This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Pokharna, H. K. Articles by Dunphy, M. J. Search for Related Content Social Bookmarking                         What's this?

Copolymers of Hydroxyethyl Methacrylate with Quadrol Methacrylate and with Various Aminoalkyl Methacrylamides as Fibroblast Cell Substrata

Departments of Chemistry and Biomedical Engineering University of Akron Akron, OH 44325

Yanmin Zhong

Departments of Chemistry and Biomedical Engineering University of Akron Akron, OH 44325

Daniel J. Smith

Departments of Chemistry and Biomedical Engineering University of Akron Akron, OH 44325

Michael J. Dunphy

Department of Chemistry Walsh College North Canton, OH 44720

Universal application of hydrophilic hydrogels like poly(hydroxy ethyl methacrylate) [p(HEMA)], as biomaterials is limited due to their inabil ity to favorably affect eukaryotic cell growth. In an attempt to favorably manipulate surface properties, a series of HEMA copolymers was made with 10-40% aminoethyl methacrylamide (AEMA), aminopropyl methacrylamide (APMA), Quadrol methacrylate (QM), N,N'-bis(2-hydroxypropyl)aminoethyl meth acrylamide (HPAEMA) or dimethylaminoethyl methacrylate (DMAEMA). Balb/c 3T3 fibroblast cell growth was observed on HEMA:AEMA (80:20), HEMA:QM (80:20) and HEMA:HPAEMA (90:10) copolymers. Cell growth on HEMA: AEMA (80:20) was comparable to HEMA:DMAEMA (60:40). HEMA copolymers containing APMA, a homolog of AEMA, exhibited cytotoxicity.

Cationic groups of primary and tertiary amines present in the HEMA copoly mer hydrogels favorably contribute to the support of cell growth. The effect of hydroxyl groups on cell growth appears to be favorable. The extent of cell growth varied with the concentration of the cationic groups in the hydrogel.

The cytotoxicity of the HEMA:APMA copolymers as compared with the bio compatibility of the HEMA:AEMA copolymers suggests that the length of the branch from the polymer chain for copolymers with primary amino groups may be a critical factor in biocompatibility.

Journal of Bioactive and Compatible Polymers, Vol. 5, No. 1, 42-52 (1990)
DOI: 10.1177/088391159000500105


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				Zainuddin, Z. Barnard, I. Keen, D. J.T. Hill, T. V. Chirila, and D. G. Harkin PHEMA Hydrogels Modified through the Grafting of Phosphate Groups by ATRP Support the Attachment and Growth of Human Corneal Epithelial Cells J Biomater Appl, September 1, 2008; 23(2): 147 - 168. [Abstract] [PDF]