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Journal of Bioactive and Compatible Polymers
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Antithrombogenic Poly(vinyl chloride) with Heparin- and/or Prostaglandin I2-Immobilized in Hydrogels

Mitsuru Akashi

Department of Applied Chemistry Faculty of Engineering, Kagoshima University 1-2140 Korimoto Kagoshima 890, Japan

Shinji Takeda

Department of Applied Chemistry Faculty of Engineering, Kagoshima University 1-2140 Korimoto Kagoshima 890, Japan

Tsuyoshi Miyazaki

Department of Applied Chemistry Faculty of Engineering, Kagoshima University 1-2140 Korimoto Kagoshima 890, Japan

Eiji Yashima

Department of Applied Chemistry Faculty of Engineering, Kagoshima University 1-2140 Korimoto Kagoshima 890, Japan

Noriyuki Miyauchi

Department of Applied Chemistry Faculty of Engineering, Kagoshima University 1-2140 Korimoto Kagoshima 890, Japan

Ikuro Maruyama

The Third Department of Internal Medicine Faculty of Medicine, Kagoshima University Usuki-cho 1208 Kagoshima 890, Japan

Toshihide Okadome

The Third Department of Internal Medicine Faculty of Medicine, Kagoshima University Usuki-cho 1208 Kagoshima 890, Japan

Yoshishige Murata

Tsukuba Research Laboratory Nippon Oil & Fats Co., Ltd. 5-10 Tokodai Tsukuba 300-26, Japan

Poly(vinyl chloride) (PVC) with heparin- and/or prostaglandin I2 (PGI2)- immobilized on crosslinked polyacrylamide hydrogels were prepared by the ad dition of the dry hydrogels to a PVC tetrahydrofuran solution. Immobilized heparin was found to be continuously released from the PVC matrix at 37 ° C in a physiological saline. Antithrombogenic activity of PVCs with heparin and/or PGI2 was evaluated by activated partial thromboplastin time (aPTT), whole blood clotting time, and inhibition of platelet aggregation. The heparin- immobilized PVC's exhibited excellent anticoagulant activity and the PGI2 immobilized PVC's completely inhibit platelet aggregation of human blood after sitting for 46 h in a physiological saline.

Journal of Bioactive and Compatible Polymers, Vol. 4, No. 1, 4-16 (1989)
DOI: 10.1177/088391158900400102
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