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Journal of Bioactive and Compatible Polymers
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Functional Monomers and Polymers CLXXVII.* Synthesis and Interaction Studies of Water Soluble Nucleic Acid Analogs: Polyethyleneimine Derivatives Containing Uracil and 5- Fluorouracil

Takehiko Wada

Department of Applied Fine Chemistry Faculty of Engineering Osaka University Suita, Osaka 565, Japan

Yoshiaki Inaki

Department of Applied Fine Chemistry Faculty of Engineering Osaka University Suita, Osaka 565, Japan

Kiichi Takemoto

Department of Applied Fine Chemistry Faculty of Engineering Osaka University Suita, Osaka 565, Japan

Nucleic acid analogs were prepared by grafting uracil and 5-fluorouracil de rivatives containing a hydroxy group onto linear polyethyleneimine. The polymers contained about 90 unit% of the nucleic acid bases, and were freely soluble in water at neutral pH value. They were found to form polymer com plexes with polynucleotide by specific base-base interaction in aqueous solu tion.

Journal of Bioactive and Compatible Polymers, Vol. 4, No. 1, 25-41 (1989)
DOI: 10.1177/088391158900400104
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