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Journal of Bioactive and Compatible Polymers
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Polycomponent Ophthalmic Inserts with Polysaccharide Support

Severian Dumitriu

Polytechnic Institute of Jassy Department of Organic and Macromolecular Chemistry 23 August 11, R-6600, Jassy, Romania

Marcel Popa

Polytechnic Institute of Jassy Department of Organic and Macromolecular Chemistry 23 August 11, R-6600, Jassy, Romania

Petre Vancea

Institute of Medicine and Pharmacy Universitatii 15 R-6600, Jassy, Romania

Danut Costin

Institute of Medicine and Pharmacy Universitatii 15 R-6600, Jassy, Romania

Ophthalmic inserts, based on xanthane modified with pilocarpine, adrena line and hydrocortisone have been prepared. The drugs were fixed in the insert by ionic bonds and gel entrapment. The in vitro release rate of pilocarpine de pended on the degree of xanthane modification and on the drug content in the polymer matrix. Inserts show a high ophthalmic tolerance indicating the potential for treatment of glaucoma.

Journal of Bioactive and Compatible Polymers, Vol. 3, No. 4, 370-389 (1988)
DOI: 10.1177/088391158800300404
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