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Journal of Bioactive and Compatible Polymers
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Biomimetic Apatite-coated PCL Scaffolds: Effect of Surface Nanotopography on Cellular Functions

Isil Gerçek Beskardes

Chemical Engineering Department, Hacettepe University Beytepe, Ankara 06800, Turkey

Menemse Gümüsderelioglu

Chemical Engineering Department, Hacettepe University Beytepe, Ankara 06800, Turkey, menemse{at}hacettepe.edu.tr

In this study, polycaprolactone (PCL) scaffolds, consisting of agglomerated microspheres with nanotopographic surface structures, were fabricated by the freeze-drying method. These scaffolds were coated with bone-like apatite by using a calcium phosphate solution similar to saturated simulated body fluid (10x SBF-like) in two different immersion periods (6 and 24 h). Scanning electron microscopic views of the 6-h treatment in 10x SBF-like solution showed formation of calcium phosphate nucleation sites on the PCL scaffolds, while the apatite particles formed characteristic cauliflower-like morphology after 24 h. The X-ray diffraction (XRD) data showed that the mineral phase was made of hydroxyapatite (HA). The osteogenic activity of untreated and SBF-treated PCL scaffolds was examined by pre-osteoblastic MC3T3 cell culture studies. Cells had attached and spread on both the PCL scaffolds and the 6-h SBF immersion-treated scaffolds.

Key Words: polycaprolactone • bone tissue engineering • simulated body fluid (SBF) • nanotopography • hydroxyapatite.

Journal of Bioactive and Compatible Polymers, Vol. 24, No. 6, 507-524 (2009)
DOI: 10.1177/0883911509349311
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