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Rechargeable Antibacterial and Antifungal Polymeric Silver Sulfadiazines

Biomedical Engineering Program, the University of South Dakota 4800 N. Career Avenue, Sioux Falls, South Dakota 57107, USA

Xinbo Sun

Biomedical Engineering Program, the University of South Dakota 4800 N. Career Avenue, Sioux Falls, South Dakota 57107, USA

Yuyu Sun

Biomedical Engineering Program, the University of South Dakota 4800 N. Career Avenue, Sioux Falls, South Dakota 57107, USA, yuyu.sun{at}usd.edu

Hao Fong

Department of Chemistry, South Dakota School of Mines and Technology 501 East St. Joseph Street, Rapid City, South Dakota 57701, USA

Poly(methyl methacrylate) (PMMA)-based rechargeable antibacterial and antifungal polymeric silver sulfadiazines were prepared by copolymerizing acryloyl sulfadiazine with methyl methacrylate and sequentially treating the copolymers with dilute silver nitrate aqueous solutions. The chemical structures of the samples were characterized by FT-IR, ¹H-NMR, XPS, and TGA analyses. On contact, the PMMA-based polymeric silver sulfadiazines provided 100% inactivation of 10⁸—10⁹ CFU/mL of Escherichia coli (Gram-negative bacteria) and Staphylococcus aureus (Gram-positive bacteria) in 10 min, and Candida tropicalis (yeast) in 30 min. Kirby—Bauer test data indicated that the antibacterial and antifungal effects were achieved through contact kill; no silver ions leached out of the new copolymers. The antibacterial and antifungal functions were stable for at least 12 months under normal storage conditions. Silver nitrate treatments regenerated any lost of antibacterial and antifungal activity; this recharging can be repeated as needed to achieve long-term protection. These properties make the new PMMA-based polymeric silver sulfadiazines attractive candidates for a broad range of medical (orthopedic), dental, and other related applications to reduce the risks of bacterial and fungal contamination on high-touch/high-risk surfaces and foreign body-related infections.

Key Words: antibacterial • antifungal • contact kill • rechargeable activity • polymeric silver sulfadiazine • PMMA-based silver sulfadiazines.

Journal of Bioactive and Compatible Polymers, Vol. 24, No. 4, 350-367 (2009)
DOI: 10.1177/0883911509340198


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