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Journal of Bioactive and Compatible Polymers
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Matrix Gene Expression in Dermal Fibroblasts Cultured on Hyaluronan-coated Polysulfone Membranes

J. Attia

Laboratory of Extracellular Matrix and Pathology, IFR 146 ICORE Faculty of Medicine, UnivCaen, 14032 Caen Cedex, France

K. Boumédiène

Laboratory of Extracellular Matrix and Pathology, IFR 146 ICORE Faculty of Medicine, UnivCaen, 14032 Caen Cedex, France

J.P. Pujol

Laboratory of Extracellular Matrix and Pathology, IFR 146 ICORE Faculty of Medicine, UnivCaen, 14032 Caen Cedex, France, jean-pierre.pujol{at}unicaen.fr

J.M. Valleton

CNRS UMR 6522, University of Rouen, 76821 Mont-Saint-Aignan, France

E. Huet

Laboratory CRRET, CNRS UMR 7149, Sciences UFR University of Paris X, 94010 Créteil, France

Q.T. Nguyen

Laboratory Polymers, Biopolymers, Surfaces FRE 3101, Sciences UFR University of Rouen, 76821 Mont-Saint-Aignan, Cedex, France

Polysulfone (PSU) membranes, coated and uncoated hyaluronan (HA), were compared for their ability to allow dermal fibroblast express genes related to extracellular matrix synthesis and remodeling. Fibroblasts type I and type III collagens were studied on both types of membranes; only type I collagen was synthesized on control cultures in plastic Petri dishes, whereas type III collagen was also expressed on PSU membranes. Expression of metalloproteinase (MMP)1, MMP3, and MMP2 was enhanced on PSU and HA-coated PSU membranes, with a lower level of MMP2 on HA-covered membranes. These membranes promote fetal-like matrices that provide good support for skin wound healing as well as favor nonscarring tissue repair.

Key Words: dermal fibroblasts • polysulfone membrane • coated polysulfone membrane • hyaluronan • hyaluronic acid • matrix gene expression • wound healing • nonscarring healing • MMP1 • enhanced MMP3 and MMP2.

Journal of Bioactive and Compatible Polymers, Vol. 24, No. 4, 329-349 (2009)
DOI: 10.1177/0883911509105847
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