Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Journal of Bioactive and Compatible Polymers
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Shin, H.-S.
Right arrow Articles by Ji Hoon Shin
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Biocompatible PEG Grafting on DLC-coated Nitinol Alloy for Vascular Stents

Hong-Sub Shin

Biomaterials Research Center, Korea Institute of Science and Technology, P. O. Box 131, Cheongryang, Seoul 130-650, Korea, Department of Chemical Engineering Sungkyunkwan University, Suwon, Korea

Kwideok Park

Biomaterials Research Center, Korea Institute of Science and Technology, P. O. Box 131, Cheongryang, Seoul 130-650, Korea

Ji Heung Kim

Department of Chemical Engineering Sungkyunkwan University, Suwon, Korea

Jae-Jin Kim

Biomaterials Research Center, Korea Institute of Science and Technology, P. O. Box 131, Cheongryang, Seoul 130-650, Korea

Dong Keun Han

Biomaterials Research Center, Korea Institute of Science and Technology, P. O. Box 131, Cheongryang, Seoul 130-650, Korea, dkh{at}kist.re.kr

Myoung-Woon Moon

Future Convergence Technology Labaratory, Korea Institute of Science and Technology, Seoul, Korea

Kwang-Ryeol Lee

Future Convergence Technology Labaratory, Korea Institute of Science and Technology, Seoul, Korea

Ji Hoon Shin

Department of Radiology, Asan Hospital, Seoul, Korea

The surfaces of Nitinol (TiNi), a popular metal alloy for arterial stents were thin-coated with diamond-like carbon (DLC) and then grafted with poly(ethylene glycol) (PEG) to increase biocompatibility. The TiNi control, DLC-coated TiNi (TiNi—DLC), and the PEG-grafted TiNi—DLC (TiNi—DLC—PEG) surface characteristics and biocompatibility were evaluated. The hydrophilicity of the TiNi—DLC—PEG significantly increased and the amount of both oxygen and nitrogen on the TiNi—DLC—PEG also increased compared to the TiNi control and TiNi—DLC due to the grafted PEG. The ratio between albumin and fibrinogen was higher on the PEG-grafted surface than the other surfaces when tested with human blood components; the platelet adhesion decreased the most on the TiNi—DLC—PEG surface, indicating improved blood compatibility. For in vivo tests using a rat model, the samples that were implanted for 6 weeks formed fibrous tissue; the tissue layer was much thinner on the PEG-grafted sample than the other two groups. The present results indicate that PEG-grafted TiNi—DLC surface may be effective in enhancing biocompatibility of blood-contacting biomaterials including vascular stents.

Key Words: stent • nitinol (TiNi alloy) • surface modification • diamond-like carbon (DLC) • poly(ethylene glycol) (PEG) • biocompatibility.

Journal of Bioactive and Compatible Polymers, Vol. 24, No. 4, 316-328 (2009)
DOI: 10.1177/0883911509104273
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?