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Peroneal Nerve Regeneration Using a Unique Bilayer Polyurethane-collagen Guide Conduit

Key Laboratory for Advanced Materials Processing Technology, Ministry of Education & Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, P.R. China, wangxiaohong{at}tsinghua.edu.cn, Institute of Life Science & Medicine, Tsinghua University Beijing 100084, P.R. China

Tongkui Cui

Key Laboratory for Advanced Materials Processing Technology, Ministry of Education & Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, P.R. China, Institute of Life Science & Medicine, Tsinghua University Beijing 100084, P.R. China

Yongnian Yan

Key Laboratory for Advanced Materials Processing Technology, Ministry of Education & Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, P.R. China, Institute of Life Science & Medicine, Tsinghua University Beijing 100084, P.R. China

Renji Zhang

Key Laboratory for Advanced Materials Processing Technology, Ministry of Education & Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, P.R. China, Institute of Life Science & Medicine, Tsinghua University Beijing 100084, P.R. China

Unique double layer polyurethane (PU)-collagen nerve guide conduits with desirable biocompatibility and mechanical properties were fabricated using a newly developed double-nozzle low-temperature deposition manufacturing (DLDM) technique. The inner collagen layer of the conduit had oriented nano-size filaments with micro-pores (pore size 20—100µm) that permitted nutrient infiltration, while the outer PU layer had micro-pores (pore size 15—20 µm) preventing fibrous tissue invasion. In vivo animal tests (n = 6) on bridging a 10 mm long peroneal nerve defect was conducted using rats. Single layer pure PU conduit (n = 6) was used as the positive control and the same size defect with no implantation (n = 2) as the negative control. Through walk track analysis as well as electrophysiological and histological evaluations of the regenerated nerves, the double layer PU-collagen conduit demonstrated better nerve repair than the controls. This new PU-collagen has the potential for significant clinical applications in peripheral nerve repair.

Key Words: peroneal nerve guide conduit • polyurethane (PU) • collagen • double-nozzle low-temperature deposition manufacturing (DLDM) • nerve regeneration.

Journal of Bioactive and Compatible Polymers, Vol. 24, No. 2, 109-127 (2009)
DOI: 10.1177/0883911508101183


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