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Journal of Bioactive and Compatible Polymers
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Design and Preparation of an Electrospun Biomaterial Surgical Patch

Hai Lu

Department of Anatomy, Key Lab of Biomechanics and Tissue Engineering Third Military Medical University, Chongqing 400038, China

Wei-Jun Chen

Department of Anatomy, Key Lab of Biomechanics and Tissue Engineering Third Military Medical University, Chongqing 400038, China

Yan Xing

Department of Anatomy, Key Lab of Biomechanics and Tissue Engineering Third Military Medical University, Chongqing 400038, China

Da-Jun Ying

Department of Anatomy, Key Lab of Biomechanics and Tissue Engineering Third Military Medical University, Chongqing 400038, China, ydj96{at}yahoo.com.cn

Bo Jiang

National Institute of Biomaterial Engineering Sichuan University, Chengdu 610064, China

A biomaterial patch of electrospun collagen type fibers was designed and produced by electrospinning seven different concentrations (8%—20% w/v) of collagen solutions. The tensile strength, yield strength, and elastic modulus of the electrospun collagen fibrous patches were found to be suitable for clinical transplantation. No significant differences versus fresh porcine pericardium as controls were observed. The SEM images of the groups showed that the patches were smooth with uniform interwoven and porous morphology. The fibrous patches were biocompatible and did not elicit local or systemic toxic effects when implanted in vivo. These electrospun collagen fibrous patches have significant potential as surgical biomaterial patches.

Key Words: Electrospun collagen • surgical patch • biomechanics • electrospun surgical patches • biocompatible electrospun patches • bioengineering • tissue engineering.

Journal of Bioactive and Compatible Polymers, Vol. 24, No. 1 Suppl, 158-168 (2009)
DOI: 10.1177/0883911509103559
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