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Fabrication and In Vitro Evaluation of Calcium Phosphate Combined with Chitosan Fibers for Scaffold Structures

State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University, Xi'an 710049, China

Dichen Li

State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University, Xi'an 710049, China, dcli{at}mail.xjtu.edu.cn

Zhongmin Jin

State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University, Xi'an 710049, China

Jue Wang

State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University, Xi'an 710049, China

Aimin Li

Institute of Orthopedic Surgery, The Fourth Military Medical University, Xi'an 710032, China

Zhen Wang

Institute of Orthopedic Surgery, The Fourth Military Medical University, Xi'an 710032, China

Zhongmin Jin

Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, LS2 9JL, UK

A rapid prototyping and rapid tool technique-based method was developed to fabricate chitosan fiber calcium phosphate cement composites (CF/CPC) for bone tissue engineering scaffold applications. The products were characterized and the in vitro performance with canine bone marrow stem cells (BMCs) on CF/CPC scaffold with controlled fiber structures evaluated. The X-ray diffraction analysis showed that about 91% of the inorganic part of the CF/CPC scaffold was hydroxyapatite (HA) and the variation in CF had little effect on the percentage of HA content. The results from in vitro study demonstrated that the interconnected macropores rapidly formed inside the CF/CPC scaffolds and that the patterns were related to the fiber structures used. The differences in the fiber structures altered the morphology of the BMCs without affecting the proliferation of the BMCs.

Key Words: tissue engineering • scaffold • rapid prototyping • fiber-reinforced composite • fiber structure • BMCs • biocompatibility.

Journal of Bioactive and Compatible Polymers, Vol. 24, No. 1 Suppl, 113-124 (2009)
DOI: 10.1177/0883911509103784


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