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Journal of Bioactive and Compatible Polymers
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Rat Cartilage Repair Using Nanophase PLGA/HA Composite and Mesenchymal Stem Cells

Huade Li

Department of Orthopaedics, The Second Affiliated Hospital Medical College, Zhejiang University, Hangzhou 310009, China

Qiang Zheng

Department of Orthopaedics, The Second Affiliated Hospital Medical College, Zhejiang University, Hangzhou 310009, China

Yuxiang Xiao

Department of Orthopaedics, The Second Affiliated Hospital Medical College, Zhejiang University, Hangzhou 310009, China

Jie Feng

Institute of Orthopaedic Research, Hangzhou 310009, China

Zhongli Shi

Institute of Orthopaedic Research, Hangzhou 310009, China

Zhijun Pan

Institute of Orthopaedic Research, Hangzhou 310009, China, cn_panzhj{at}yahoo.com.cn

Biodegradable polymer/bioceramic composite poly(lactide- coglycolide)/hydroxyapatite(PLGA/HA) was studied for bone tissue engineering. The PLGA/HA composite was evaluated as a scaffold with the ability for mesenchymal stem cells (MSC) to participate in cartilage repair. The PLGA/HA composite and the PLGA/HA composite cultured with MSC were transplanted into cartilage defects created in rats. The PLGA/HA-MSC and PLGA/HA had better tissue morphology, structure integrity, matrix staining, and much thicker newly formed cartilage than the control group. The histological score for PLGA/ HA-MSC better than that for PLGA/HA; it appears that the MSC plays an important role in tissue repair. Based on these results, using PLGA/HA as the tissue scaffold and the addition of MSC significantly enhances cartilage repair.

Key Words: poly(lactide-co-glycolide) • hydroxyapatite • PLGA/HA • tissue scaffolds • mesenchymal stem cells • cartilage repair • cartilage regeneration • tissue engineering • phenotype cells.

Journal of Bioactive and Compatible Polymers, Vol. 24, No. 1, 83-99 (2009)
DOI: 10.1177/0883911508100655
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