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Journal of Bioactive and Compatible Polymers
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Hyaluronic Acid/Polylysine Hydrogel as a Transfer System for Transplantation of Neural Stem Cells

Yong-Juan Ren

Biomaterials Laboratory, Department of Materials Science and Engineering, Tsinghua University Beijing 100084, People's Republic of China

Zi-You Zhou

Biomaterials Laboratory, Department of Materials Science and Engineering, Tsinghua University Beijing 100084, People's Republic of China

Fu-Zhai Cui

Biomaterials Laboratory, Department of Materials Science and Engineering, Tsinghua University Beijing 100084, People's Republic of China, Cuifz{at}mail.tsinghua.edu.cn

Ying Wang

Beijing Institute of Neuroscience, Capital Medical University Beijing 100054, People's Republic of China

Jun-Peng Zhao

Beijing Institute of Neuroscience, Capital Medical University Beijing 100054, People's Republic of China

Qun-Yuan Xu

Beijing Institute of Neuroscience, Capital Medical University Beijing 100054, People's Republic of China

Graft integration and survival are major factors that limit cell therapy for diseases and injury in the central nervous system. Efforts to improve graft survival and integration have focused on the development of biocompatible scaffolds to support neural cells. In this study, rat neural stem cells (NSC), including neurospheres and single cells, were seeded into hyaluronic acid/polylysine hydrogels. Confocal microscopy was used to noninvasively investigate the key cell phonotypes. After culture for 5 days, single NSC had survived and differentiated into neurons and astrocytes, while neurosphereforming cells had migrated from their original aggregate and maintained the NSC phonotype. These studies, carried out in the absence of serum, identified HA/polylysine hydrogels as potential synthetic cell carriers for transplantation of NSC.

Key Words: neural stem cell • tissue engineering • tissue scaffolds • stem cell transplantation • hydrogels • hyaluronic acid hydrogels • polylysine hydrogels • hyaluronic acid/polylysine hydrogels.

Journal of Bioactive and Compatible Polymers, Vol. 24, No. 1, 56-62 (2009)
DOI: 10.1177/0883911508099472
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[Abstract] [PDF]