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New Multicomponent Bioerodible Electrospun Nanofibers for Dual-controlled Drug Release

Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Application - INSTM Consortium Reference Center, Department of Chemistry & Industrial Chemistry University of Pisa, Pisa, Italy

F. Chiellini

Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Application - INSTM Consortium Reference Center, Department of Chemistry & Industrial Chemistry University of Pisa, Pisa, Italy

E. Chiellini

Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Application - INSTM Consortium Reference Center, Department of Chemistry & Industrial Chemistry University of Pisa, Pisa, Italy, , emochie{at}dcci.unipi.it

L. Nikkola

Department of Biomedical Engineering, Tampere University of Technology, Tampere, Finland

N. Ashammakhi

Department of Biomedical Engineering, Tampere University of Technology, Tampere, Finland

The objective of this study was to evaluate the bioerodible polymer poly(maleic anhydride-alt-2-methoxyethyl vinyl ether) n-butyl hemiester, for multicomponent drug-loaded nanofibers produced by electrospinning. Diclofenac sodium (DS) and human serum albumin (HSA) were used as conventional drug and biopharmaceutical models. The influence of drug loading was correlated to beads presence, morphology and fibers diameter. When DS and HSA were loaded separately, a uniform distribution within fibers and beads was observed. However, when both components were loaded simultaneously, a heterogeneous distribution of DS was observed with a prominent amount in the cylindrical beads. The in vitro drug release evaluation from these nanomaterials displayed an independent delivery of the two components. These studies support the feasibility of multicomponent, bioerodible polymeric nanofibers preparation loaded with combination of traditional drugs and proteins.

Key Words: electrospinning • nanotechnology • nanofibers • drug release.

Journal of Bioactive and Compatible Polymers, Vol. 23, No. 5, 423-443 (2008)
DOI: 10.1177/0883911508093357


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