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Journal of Bioactive and Compatible Polymers, Vol. 23, No. 4, 367-380 (2008)
DOI: 10.1177/0883911508093389

Chitosan Beads as Templates for Layer-by-Layer Assembly and their Application in the Sustained Release of Bioactive Agents

Jessica M.R. Grech

3B's Research Group- Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering Campus de Gualtar, Braga, 4710-057 Portugal, IBB — Institute for Biotechnology and Bioengineering PT Government Associated Laboratory, Braga, Portugal

Joao F. Mano

3B's Research Group- Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering Campus de Gualtar, Braga, 4710-057 Portugal, jmano{at}dep.uminho.pt, IBB — Institute for Biotechnology and Bioengineering PT Government Associated Laboratory, Braga, Portugal

Rui L. Reis

3B's Research Group- Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering Campus de Gualtar, Braga, 4710-057 Portugal, IBB — Institute for Biotechnology and Bioengineering PT Government Associated Laboratory, Braga, Portugal

Uncoated chitosan beads and chitosan beads coated with hyaluronic acid/chitosan (HA/Ch) multilayers, were used to investigate the controlled release of gentamicin sulphate (GS). Greater encapsulation efficiency was observed for the layer—by-layer multilayer coated beads. The in vitro drug release was in a slower sustained manner compared with noncoated chitosan beads. The differences in in vitro drug release results may be explained by the barrier effect of the coating that impedes diffusion of GS and supporting complementary water uptake. These findings indicated that a slower sustained release of gentamicin can be obtained using multilayer coatings of HA/Ch on chitosan beads and that this process could be used as a drug delivery system. In addition, agglomerates of these bead could provide a porous support in tissue engineering applications.

Key Words: layer-by-layer • chitosan beads • bead coatings • drug release • gentamicin delivery • controlled delivery • tissue engineering • scaffold.


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