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Journal of Bioactive and Compatible Polymers
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Chitin Nanofibrils Linked to Chitosan Glycolate as Spray, Gel, and Gauze Preparations for Wound Repair

M. Mattioli-Belmonte

Department of Molecular Pathology and Innovative Therapies - Histology - School of Medicine - Marche Polytechnic University, Italy, m.mattioli{at}univpm.it

A. Zizzi

Department of Molecular Pathology and Innovative Therapies - Histology - School of Medicine - Marche Polytechnic University, Italy

G. Lucarini

Department of Molecular Pathology and Innovative Therapies - Histology - School of Medicine - Marche Polytechnic University, Italy

F. Giantomassi

Department of Molecular Pathology and Innovative Therapies - Histology - School of Medicine - Marche Polytechnic University, Italy

G. Biagini

Department of Molecular Pathology and Innovative Therapies - Histology - School of Medicine - Marche Polytechnic University, Italy

G. Tucci

Operative Unit of Dermatology, INRCA, Ancona , Italy

F. Orlando

Experimental Animal Unit, INRCA, Ancona, Italy

M. Provinciali

Experimental Animal Unit, INRCA, Ancona, Italy

F. Carezzi

Mavi Sud, Aprilia, Italy

P. Morganti

Visiting Professor China Medical University, Shenyang - R&D Director Mavi Sud, Aprilia, Italy

Recent advances in process chemistry have made it possible to make chitosan and chitin nanofibril materials more flexible and useful for the development of new biorelated products. In this study, the effectiveness of three chitin nanofibril/chitosan glycolate-based preparations, a spray (Chit-A), a gel (Chit-B), and a gauze (Chit-C), in healing cutaneous lesions are assessed macroscopically and by light microscopy immunohistochemistry. These evaluations are compared to the results obtained using a laser co-treatment. The wound repair provided by the three preparations is clearly evident even without the synergistic effect of the laser co-treatment. These results confirm the effectiveness of chitin nanofibril/chitosan glycolate-based products in restoring subcutaneous architecture. The spray seems to be most effective in healing superficial lesions, including extensive ones; the gel is more effective in repairing shallow lesions as well as an aesthetic factor while the gauze is effective in slow-healing dermo-epidermal wounds.

Key Words: chitin nanofibrils • chitosan glycolate • wound healing • immunohistochemistry • cutaneous lesions • laser treatment.

Journal of Bioactive and Compatible Polymers, Vol. 22, No. 5, 525-538 (2007)
DOI: 10.1177/0883911507082157
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