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Journal of Bioactive and Compatible Polymers
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Preparation of PLLA/PEG Nanofibers by Electrospinning and Potential Applications

M. Spasova

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

O. Stoilova

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

N. Manolova

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

I. Rashkov

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria, rashkov{at}polymer.bas.bg

G. Altankov

Institute of Biophysics, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

Poly(L-lactide) (PLLA)/polyethylene glycol (PEG) mixed solutions were successfully electrospun into micro-or nanofibrous polymer mats. The fiber diameter was in the range 100nm-6µm. The effect of the concentration of the spinning solutions and the ratio of PLLA/PEG on the fiber diameter and morphology was investigated. The hydrophilicity was tuned by varying the PLLA/PEG ratio. The tissue compatibility of the electrospun nanofibrous scaffolds was screened using two different cell models of human dermal fibroblasts and the osteoblast-like cell line MG-63. Both types of cells attached uniformly and approximately equally to all PLLA/PEG nanofibers. In long-term cultures osteoblast-like cells tend to spatially organize in tissue-like structure, particularly within the scaffold with the highest PEG content (PLLA/PEG at weight ratio 70/30). These results indicate that PLLA mixed with hydrophilic PEG produces a promising new biocompatible material for engineering scaffolds.

Key Words: electrospinning • nanofibers • poly(L-lactide) • poly(ethylene glycol) • fibroblasts • osteoblasts • nanoscale fibers • tissue engineering • cell ingrowth

Journal of Bioactive and Compatible Polymers, Vol. 22, No. 1, 62-76 (2007)
DOI: 10.1177/0883911506073570
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