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Journal of Bioactive and Compatible Polymers, Vol. 22, No. 1, 30-41 (2007)
DOI: 10.1177/0883911506073639
© 2007 SAGE Publications

Pulmonary Anti-inflammatory Effects of Chitosan Microparticles Containing Betamethasone

Y. C. Huang

Graduate Institute of Life Science, National Defense Medical Center, University of National Defense, Taipei, Taiwan, yuh{at}sfu.ca

A. Vieira

Endocrine and Metabolic Research Laboratory, Faculty of Applied Sciences, Simon Fraser University, Burnaby, B.C., Canada

M. K. Yeh

Department of Pharmacy, Tri-service General Hospital, National Defense Medical Center, University of National Defense, Taipei, Taiwan

C. H. Chiang

School of Pharmacy, National Defense Medical Center, University of National Defense, Taipei, Taiwan

Chitosan microparticles (CMs) are of potential interest for controlled delivery of therapeutic agents to cells and tissues, especially to mucosal-epithelial surfaces in the body. CM incorporation efficiency and release kinetics for betamethasone (B), an epimeric synthetic glucocorticoid, were investigated. Evidence for mild but significant inflammatory reactions in rat lung exposed to high CM concentrations was observed. Inflammation in the rat lung was significantly decreased by inhalation of B-loaded CMs (BCMs). Decreases in bronchoalveolar lavage fluid protein, content of polymorphonuclear neutrophils, lactate dehydrogenase (LDH) activity, lung tissue myeloperoxidase (MPO) activity, and leukocyte infiltration were observed. For all biochemical parameters tested, CMs loaded with 1.0-1.2mg/kg B decrease the inflammation by 1.63±0.14 fold, to near air-inhalation control levels. Thus, the drug was efficiently delivered and active in the pulmonary tissues by this technique.

Key Words: betamethasone • microparticles • chitosan • pulmonary delivery • inflammation • bronchoalveolar • MPO activity • leukocyte infiltration • polymorphonuclear neutrophils • lactate dehydrogenase activity


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