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Journal of Bioactive and Compatible Polymers
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Evaluation of Cell Adhesion and Proliferation on a Novel Tissue Engineering Scaffold Containing Chitosan and Hydroxyapatite

Wanpen Tachaboonyakiat

Department of Materials Science, Faculty of Science, Chulalongkorn University, Phyathai, Bangkok 10330, Thailand

Daisuke Ogomi

Nitto Denko Corporation, 455-6 Hongo, Minogo, Onomichi, Hiroshima 722-0212, Japan

Takeshi Serizawa

Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan

Mitsuru Akashi

Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Yamada-oka, Suita 565-0871, Japanakashi{at}chem.eng.osaka-u.ac.jp

Porous chitosan-hxdroxyapatite hybrids were developed by partial enzymatic degradation [14] of the chitin/chitosan surface using chitosanase and lysozyme. This article evaluates the influence of chitosan and hydroxyapatite components, substrate roughness, stability, as well as surface porosity produced by enzymatic hydrolysis to cell adhesion and proliferation. L929 mouse fibroblastic lung cells were cultured on enzymatic degraded porous chitosan-hydroxyapatite hybrids. The presence of hydroxyapatite and porosity produced by partial lysozyme hydrolysis enhance cell proliferation. Besides, cell adhesion and proliferation are primarily dependent on substrate roughness and stability.

Key Words: porous • chitosan-hydroxyapatite • enzymatic hydrolysis • biocompatibility

Journal of Bioactive and Compatible Polymers, Vol. 21, No. 6, 579-589 (2006)
DOI: 10.1177/0883911506070441
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