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Journal of Bioactive and Compatible Polymers
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Core/Shell Macrobeads for the Protection of Islets from Immune System Rejection

Young Hwan Choi

Department of Polymer Science and Engineering, Hannam University, 133 Ojeong Dong, Daedeog Ku, Taejeon, Korea, 306-791

Jin Ho Lee

Department of Polymer Science and Engineering, Hannam University, 133 Ojeong Dong, Daedeog Ku, Taejeon, Korea, 306-791

Soon Hong Yuk

Department of Polymer Science and Engineering, Hannam University, 133 Ojeong Dong, Daedeog Ku, Taejeon, Korea, 306-791, shyuk{at}hannam.ac.kr

Sun Hee Suh

Department of Immunology, The Catholic University of Korea, St Mary’s Hospital, 505 Banpo Dong, Seocho Ku, Seoul, Korea, 137-040

Kun-Ho Yoon

Department of Immunology, The Catholic University of Korea, St Mary’s Hospital, 505 Banpo Dong, Seocho Ku, Seoul, Korea, 137-040

Core/shell macrobeads, composed of a hydrogel core and a biodegradable polymeric shell, were designed and evaluated for the protection of islets from both fibrous tissue development as well as the modulation of the immune system rejection response. The core/shell macrobeads (2,000µm diameter) were prepared with approximately 150µm thick polymeric shells. Islets isolated from pancreas of C57/BL6 mice were encapsulated in these core/shell macrobeads. The islets-loaded core/shell macrobeads were planted in the peritoneal cavity of diabetes mellitus-induced C57/BL6 mice and the blood glucose concentrations were measured.

Key Words: biodegradeable • hydrogel • coreshell • islets • macrobeads • immune system • blood glucose

Journal of Bioactive and Compatible Polymers, Vol. 21, No. 1, 71-81 (2006)
DOI: 10.1177/0883911506060146
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