This Article Free Full Text (Free PDF) Free References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (7) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Wang, X. Articles by Zhang, R. Search for Related Content Social Bookmarking                         What's this?

A Comparison of Chitosan and Collagen Sponges as Hemostatic Dressings

Key Laboratory for Advanced Manufacturing by Materials Processing Technology and Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, P.R. China, Institute of Life Science and Medicine, Tsinghua University, Beijing 100084, P.R. China, wangxiaohong{at}tsinghua.edu.cn

Yongnian Yan

Key Laboratory for Advanced Manufacturing by Materials Processing Technology and Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, P.R. China, Institute of Life Science and Medicine, Tsinghua University, Beijing 100084, P.R. China

Renji Zhang

Key Laboratory for Advanced Manufacturing by Materials Processing Technology and Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, P.R. China, Institute of Life Science and Medicine, Tsinghua University, Beijing 100084, P.R. China

The hemostatic capability, adhesion ability and biocompatibility of chitosan sponges were compared with commercial collagen sponges. The chitosan sponges were briefly immersed in an aqueous 20% ammonia solution before being applied to a rabbit cervical vein wound. The total amount of bleeding from the injured veins until hemostasis was similar for both chitosan and collagen sponges. The complete hemostasis success rates for both the chitosan and collagen sponges were also similar. Under hemostasis, the chitosan sponges strongly adhered to the surface of the rabbit muscles, whereas the collagen sponges were easily detached from the muscles. Under wet conditions, however, there was no significant difference in the adhesive ability between the two sponges. During implantation, the chitosan sponges were much more flexible and resistant to breakage than the collagen sponges. The biocompatibilities and biodegradation rates of the two sponges were totally different after subcutaneous implantation in rabbits. The chitosan sponge was degraded much slower than the collagen sponge, while tissue responses for the chitosan sponges were much greater than for the collagen sponges.

Key Words: hemostasis • chitosan • collagen • adhesion • biocompatibility

Journal of Bioactive and Compatible Polymers, Vol. 21, No. 1, 39-54 (2006)
DOI: 10.1177/0883911506060201


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				Shengjie Li, Zhuo Xiong, Xiaohong Wang, Yongnian Yan, Haixia Liu, and Renji Zhang Direct Fabrication of a Hybrid Cell/Hydrogel Construct by a Double-nozzle Assembling Technology Journal of Bioactive and Compatible Polymers, May 1, 2009; 24(3): 249 - 265. [Abstract] [PDF]

				H. Chen and M. Fan Chitosan/Carboxymethyl Cellulose Polyelectrolyte Complex Scaffolds for Pulp Cells Regeneration Journal of Bioactive and Compatible Polymers, September 1, 2007; 22(5): 475 - 491. [Abstract] [PDF]

				M. Mattioli-Belmonte, A. Zizzi, G. Lucarini, F. Giantomassi, G. Biagini, G. Tucci, F. Orlando, M. Provinciali, F. Carezzi, and P. Morganti Chitin Nanofibrils Linked to Chitosan Glycolate as Spray, Gel, and Gauze Preparations for Wound Repair Journal of Bioactive and Compatible Polymers, September 1, 2007; 22(5): 525 - 538. [Abstract] [PDF]