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Journal of Bioactive and Compatible Polymers
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Biodistribution and Antitumor Activity Induced by Carboxymethylcellulose Conjugates

Constantin V. Uglea

University of Medicine and Pharmacy, Department of Biomedical Engineering, Str. Universita't ii 16, Iassy, 700115, Romania; cuglea{at}umfiasi.ro

Anton Pârv

Maria Corjan

Alina D. Dumitriu

University "Al. I. Cuza", Department of Biology, Iassy, Romania

Raphael M. Ottenbrite

Virginia Commonwealth University, Richmond, USA

New polymers with antitumor activity were synthesized by conjugating ethyl p-aminobenzoate (benzocaine) and N-hydroxy-2,3-dihydroxybenzamide (Didox) onto carboxymethylcellulose (CMC) and oxidized CMC. The biological tests (in vitro and in vivo) for these CMC derivatives exhibited prolonged half-life in serum, accumulation in the solid tumors, and inhibition of the tumor growth. The latter effect was attributed to the permeability and retention (EPR) effect.

Key Words: carboxymethylcellulose conjugates • bioactive polymers • antitumor activity • tumor accumulation • prolonged serum half-life • drug permeability and retention

Journal of Bioactive and Compatible Polymers, Vol. 20, No. 6, 571-583 (2005)
DOI: 10.1177/0883911505059251
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