Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Journal of Bioactive and Compatible Polymers
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Yu, G.
Right arrow Articles by Shen, J.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Cholesterol Tethered Poly(DL-Lactic Acid) for Promoting Osteoblast Attachment and Growth

Guanhua Yu

Department of Polymer Science and Engineering, Zhejiang University Hangzhou 310027, China

Jian Ji

Department of Polymer Science and Engineering, Zhejiang University Hangzhou 310027, China; jianji{at}mail.hz.zj.cn

Jiacong Shen

Department of Polymer Science and Engineering, Zhejiang University Hangzhou 310027, China

In poly(DL-lactic acid)-cholesterol oligomers (LC), a novel cholesterol modified poly(DL-lactic acid) (PLA), was synthesized via bulk polymerization of DL-lactide using cholesterol initiator. Gel permeation chromatography (GPC) and 1H nuclear magnetic resonance spectroscopy (1H-NMR) results indicated a narrow molecular weight distribution of poly (DL-lactic acid)-cholesterol oligomers (LC). Mouse MC3T3 osteoblast-like cells were selected as a model system to test the cell behavior of cholesterol modified PLA substrates. The osteoblast attachment, proliferation, and viability revealed that the cholesterol modified PLA was significantly osteoblast compatible and may have potential as a bone tissue engineering material.

Key Words: cholesterol • osteoblast • poly(DL-lactic acid) • bone • tissue engineering

Journal of Bioactive and Compatible Polymers, Vol. 20, No. 6, 527-540 (2005)
DOI: 10.1177/0883911505059047
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?